A 2026 randomized controlled trial published in Ozone: Science and Engineering found that weekly endovaginal medical ozone treatment significantly reduced pelvic pain and improved quality of life, sexual function, and anxiety symptoms in women with endometriosis, with no serious adverse effects reported.

In a landmark move for integrative medicine, Brazil’s Federal Council of Medicine has officially regulated ozone therapy for medical use under Federal Law 14,648 and Resolution 2,445/2025. The decision recognises ozone therapy as a complementary medical procedure for treating wounds and musculoskeletal pain, marking a historic shift after years of opposition and setting a precedent for broader global acceptance.

VIRTUAL GENERAL ASSEMBLY OF ISCO3 , Election of the Governing Board (Art. 20 statutes) dated January 10, 2025

CHILE BEGINS LEGISLATIVE PROCESS TO REGULATE OZONE THERAPY